The double-edged roles of ROS in cancer prevention and therapy

被引：577

作者：

Wang, Yawei ^{[1
,2
]}

Qi, Huan ^{[2
]}

Liu, Yu ^{[1
,2
]}

Duan, Chao ^{[1
,2
]}

Liu, Xiaolong ^{[2
]}

Xia, Tian ^{[2
]}

Chen, Di ^{[2
]}

Piao, Hai-long ^{[2
,3
]}

Liu, Hong-Xu ^{[1
]}

机构：

[1] China Med Univ, Liaoning Canc Hosp & Inst, Dept Thorac Surg, Canc Hosp, Shenyang 110042, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[3] China Med Univ, Sch Life Sci, Dept Biochem & Mol Biol, Shenyang 110122, Peoples R China

来源：

THERANOSTICS | 2021年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL RESPIRATORY-CHAIN; REDUCTASE INHIBITOR ETHASELEN; OXYGEN SPECIES ROS; CELL-CYCLE ARREST; OXIDATIVE STRESS; NADPH OXIDASE; LUNG-CANCER; HYDROGEN-PEROXIDE; PROSTATE-CANCER; BUTHIONINE SULFOXIMINE;

D O I：

10.7150/thno.56747

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative metabolism and are associated with a number of human diseases. The reprogramming of redox metabolism induces abnormal accumulation of ROS in cancer cells. It has been widely accepted that ROS play opposite roles in tumor growth, metastasis and apoptosis according to their different distributions, concentrations and durations in specific subcellular structures. These double-edged roles in cancer progression include the ROS-dependent malignant transformation and the oxidative stress-induced cell death. In this review, we summarize the notable literatures on ROS generation and scavenging, and discuss the related signal transduction networks and corresponding anticancer therapies. There is no doubt that an improved understanding of the sophisticated mechanism of redox biology is imperative to conquer cancer.

引用

页码：4839 / 4857

页数：19

共 254 条

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