Dental stem cells for tooth regeneration and repair

被引：55

作者：

Mantesso, Andrea ^{[1
,2
]}

Sharpe, Paul ^{[1
,3
,4
]}

机构：

[1] Kings Coll London, Inst Dent, Guys Hosp, Dept Craniofacial Dev, London SE1 9RT, England

[2] Univ Sao Paulo, Inst Dent, Dept Oral Pathol, BR-05508900 Sao Paulo, Brazil

[3] Guys & St Thomas NHS Fdn Trust Hosp, Biomed Res Ctr, London SE1 9RT, England

[4] Kings Coll London, MRC Ctr Transplantat, London SE1 9RT, England

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2009年 / 9卷 / 09期

基金：

英国医学研究理事会;

关键词：

dental stem cells; tooth development; tooth engineering; tooth repair; SIDE POPULATION CELLS; HUMAN ARTICULAR CHONDROCYTES; AMELOBLAST-LIKE CELLS; HUMAN BONE-MARROW; NEURONS IN-VITRO; PERIODONTAL-LIGAMENT; PULP CELLS; ODONTOBLAST DIFFERENTIATION; CALCIUM HYDROXIDE; PROGENITOR CELLS;

D O I：

10.1517/14712590903103795

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Mesenchymal stem cells (MSCs) resident in bone marrow are one of the most studied and clinically important populations of adult stem cells. Cells with, similar proper-ties to these MSCs have been described in several different tooth tissues and the potential ease with which these dental MSCs could be obtained from patients has prompted great interest in these cells as a source of MSCs for cell-based therapeutics. In this review we address the current state of knowledge regarding these cells, their properties, origins, locations, functions and potential uses in tooth tissue engineering and repair. We discuss some of the key controversies and outstanding issues, not least of which whether dental stem cells actually exist.

引用

页码：1143 / 1154

页数：12

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