Hypoglycemic effect of the total flavonoid fraction from Folium Eriobotryae

被引：59

作者：

Lue, H. ^{[1
]}

Chen, J. ^{[1
]}

Li, W. L. ^{[1
]}

Ren, B. R. ^{[1
]}

Wu, J. L. ^{[1
]}

Zhang, H. Q. ^{[1
]}

机构：

[1] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Jiangsu, Peoples R China

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 10期

关键词：

Folium Eriobotryae (Eriobotrya japonica (Thunb.) Lindl.); Flavonoid fraction; Hypoglycemic activity; DIABETES-MELLITUS; JAPONICA; LEAVES;

D O I：

10.1016/j.phymed.2009.03.024

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The antidiabetic effect of the total flavonoids fraction from leaves of Eriobotrya japonica (EJF) was evaluated through normal and streptozotocin-induced diabetic mice with graded oral doses of 150, 300, 450 mg/kg for 7 days or 14 days. The result showed that the dose of 300mg/kg and 450mg/kg resulted significant hypoglycemic effect on normal mice, the dose of 300 mg/kg induced significant decrease in plasma glucose concentration (PGC), glycosylated serum protein (GSP), total cholesterol (TC) and triglyceride (TG), and significant increase in superoxide dismutase (SOD) activity and serum insulin level in streptozotocin-diabetic mice. These results suggested that EJF has hypoglycemic potential. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：967 / 971

页数：5

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