Preparation and characterization of amorphous cefuroxime axetil drug nanoparticles with novel technology: high-gravity antisolvent precipitation

被引:100
作者
Chen, Jian-Feng
Zhang, Ji-Yao
Shen, Zhi-Gang
Zhong, Jie
Yun, Jimmy
机构
[1] Beijing Univ Chem Technol, Sin China Technol Ctr, Key Lab Nanomat, Minist Educ, Beijing 100029, Peoples R China
[2] Nanomat Technol Pte Ltd, Singapore 139959, Singapore
关键词
D O I
10.1021/ie060445h
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Amorphous nanoparticles of cefuroxime axetil (CFA), a kind of poorly water-soluble antibiotic drug, were prepared at massive production rate by a novel continuous process, the high-gravity antisolvent precipitation (HGAP). The produced CFA nanoparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FTIR), powder X-ray diffraction (XRD), specific surface area analysis (BET), differential scanning calorimetry (DSC), and a dissolution test. The mean particle size of CFA was about 300 nm with a narrow distribution from 100 to 400 nm. The specific surface area reached up to 8.67 m(2)/g, which was about 4 times higher than that of the commercial spray-dried CFA. And the results of the dissolution test showed that dissolution rate of the former were higher than that of the latter. Hence it is proved the HGAP technique offers a direct and continuous process for mass-production of drug nanoparticles.
引用
收藏
页码:8723 / 8727
页数:5
相关论文
共 31 条
[11]   Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems [J].
Hu, JH ;
Johnston, KP ;
Williams, RO .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 20 (03) :295-303
[12]  
Kanfer I., 2000, J PHARM PHARM SCI, V5, P1
[13]   Nanosizing: a formulation approach for poorly-water-soluble compounds [J].
Merisko-Liversidge, E ;
Liversidge, GG ;
Cooper, ER .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 18 (02) :113-120
[14]   Protein-conjugated nanoparticles from rapid expansion of supercritical fluid solution into aqueous solution [J].
Meziani, MJ ;
Sun, YP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (26) :8015-8018
[15]   Micronization of pharmaceutical substances in a spiral jet mill [J].
Midoux, N ;
Hosek, P ;
Pailleres, L ;
Authelin, JR .
POWDER TECHNOLOGY, 1999, 104 (02) :113-120
[16]   THE EFFECT OF PARTICLE-SIZE AND SHAPE ON THE SURFACE SPECIFIC DISSOLUTION RATE OF MICROSIZED PRACTICALLY INSOLUBLE DRUGS [J].
MOSHARRAF, M ;
NYSTROM, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 122 (1-2) :35-47
[17]   Nanosuspensions as particulate drug formulations in therapy Rationale for development and what we can expect for the future [J].
Muller, RH ;
Jacobs, C ;
Kayser, O .
ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :3-19
[18]   Nanosuspensions for the formulation of poorly soluble drugs - I. Preparation by a size-reduction technique [J].
Muller, RH ;
Peters, K .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 160 (02) :229-237
[19]   Micron-size drug particles:: Common and novel micronization techniques [J].
Rasenack, N ;
Müller, BW .
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2004, 9 (01) :1-13
[20]   Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs [J].
Rasenack, N ;
Müller, BW .
PHARMACEUTICAL RESEARCH, 2002, 19 (12) :1894-1900