Preparing functional bis(indole) pyrazine by stepwise cross-coupling reactions: An efficient method to construct the skeleton of dragmacidin D

被引：58

作者：

Yang, CG ^{[1
]}

Liu, G ^{[1
]}

Jiang, B ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 26期

关键词：

D O I：

10.1021/jo026450m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct approach for selective construction of properly substituted bis(indole) pyrazine, the skeleton of a marine alkaloid dragmacidin D, has been developed. The key steps involved the regioselective introduction of two indole units, using the palladium(0)-catalyzed Suzuki and the Stille cross-coupling reactions sequentially.

引用

页码：9392 / 9396

页数：5

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