Enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers

被引：158

作者：

Belanger, Etienne ^{[1
]}

Cantin, Katy ^{[1
]}

Messe, Olivier ^{[1
]}

Tremblay, Melanie ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Canada Res Chair Organ & Med Chem, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 05期

关键词：

D O I：

10.1021/ja067501q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary -fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.

引用

页码：1034 / 1035

页数：2

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