Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

被引：380

作者：

Seifert, Jessica R. K. ^{[1
]}

Mlodzik, Marek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg2042

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.

引用

页码：126 / 138

页数：13

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