Design, synthesis, and validation of a branched flexible linker for bioactive peptides

被引：16

作者：

Bowen, Martina E.

Monguchi, Yasunari

Sankaranarayanan, Rajesh

Vagner, Josef

Begay, Lucinda J.

Xu, Liping

Jagadish, Bhumasamudram

Hruby, Victor J.

Gillies, Robert J.

Mash, Eugene A. ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Arizona Canc Ctr, Dept Biochem & Mol Biophys, Tucson, AZ 85724 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 05期

关键词：

D O I：

10.1021/jo062276g

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

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收藏

页码：1675 / 1680

页数：6

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