Cholesterol depletion inhibits fatty acid uptake without affecting CD36 or caveolin-1 distribution in adipocytes

被引：18

作者：

Covey, Scott D.

Brunet, Rachelle H.

Gandhi, Shephali G.

McFarlane, Nicole

Boreham, Douglas R.

Gerber, Gerhard E.

Trigatti, Bernardo L.

机构：

[1] Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Hamilton, ON L8N 3Z5, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 355卷 / 01期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

adipocyte; caveolae; caveolin-1; CD36; cholesterol; fatty acid; lipid raft; PLASMA-MEMBRANE; MEDIATED TRANSPORT; RECEPTOR; CELLS;

D O I：

10.1016/j.bbrc.2007.01.135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolin-1 and CD36 are plasma membrane fatty acid binding proteins that participate in adipocyte fatty acid uptake and metabolism. Both are associated with cholesterol-enriched caveolae/lipid rafts in the plasma membrane that are important for long chain fatty acid uptake. Depletion of plasma membrane cholesterol reversibly inhibited oleate uptake by adipocytes without altering the amount or the cell surface distribution of either caveolin-1 or CD36. Cholesterol levels thus regulate fatty acid uptake by adipocytes via a pathway that does not involve altered cell surface localization of caveolin-1 or CD36. (c) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：67 / 71

页数：5

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