Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men

被引：15

作者：

Colin, Jessie ^{[1
]}

Gaumer, Sebastien ^{[1
]}

Guenal, Isabelle ^{[1
]}

Mignotte, Bernard ^{[1
]}

机构：

[1] Univ Versailles St Quentin, Ecole Prat Hautes Etud, CNRS, UMR8159,Lab Genet & Biol Cellulaire, F-78035 Versailles, France

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Apoptosis; Apoptosome; Mitochondria; Caspase; Apaf-1; CED-4; nematode; Drosophila; Bcl-2; family; Review; DROSOPHILA-CASPASE DRONC; PROGRAMMED CELL-DEATH; CAENORHABDITIS-ELEGANS; CYTOCHROME-C; DEVELOPMENTAL APOPTOSIS; JNK PATHWAY; GENE CED-3; ACTIVATION; BAX; PROTEASE;

D O I：

10.2741/3517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Initiator caspases are activated within specialized complexes, one of which is the apoptosome. The apoptosome is always constituted by at least an initiator caspase and a caspase activator. Apoptosome activation enables maturation of the associated caspase and constitutes a key step for cell fate. This activating complex is found throughout metazoans but its composition and regulation seem slightly different from one species to another. This review focuses on the composition and activation of the apoptosome in different species and details the role of mitochondrial factors and Bcl-2 family members in this activation.

引用

页码：4127 / 4137

页数：11

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