The ribosome - a macromolecular machine par excellence

被引：31

作者：

Frank, J ^{[1
]}

机构：

[1] Hlth Res Inc, Howard Hughes Med Inst, Albany, NY 12201 USA

[2] Hlth Res Inc, Wadsworth Ctr, Albany, NY 12201 USA

[3] SUNY Albany, Dept Biomed Sci, Albany, NY 12201 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 06期

关键词：

D O I：

10.1016/S1074-5521(00)00127-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ribosome is the site in the cell where proteins are synthesized. Cryo-electron microscopy and X-ray crystallography have revealed the ribosome as a particle made of two subunits, each formed as an intricate mesh of RNAs and many proteins. Ligand-binding experiments followed by cryo-electron microscopy have helped to determine some of the key stages of interaction between the ribosome and the main ligand molecules.

引用

页码：R133 / R141

页数：9

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