High seroprevalence of Epstein-Barr virus in children with multiple sclerosis

被引:159
作者
Pohl, D.
Krone, B.
Rostasy, K.
Kahler, E.
Brunner, E.
Lehnert, M.
Wagner, H. -J.
Gaertner, J.
Hanefeld, F.
机构
[1] Univ Gottingen, Dept Pediat & Pediat Neurol, D-3400 Gottingen, Germany
[2] Univ Gottingen, Dept Virol, D-3400 Gottingen, Germany
[3] Univ Gottingen, Dept Med Stat, D-3400 Gottingen, Germany
[4] Univ Giessen, Dept Pediat, D-35390 Giessen, Germany
关键词
D O I
10.1212/01.wnl.0000247665.94088.8d
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis ( MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
引用
收藏
页码:2063 / 2065
页数:3
相关论文
共 10 条
[1]   Epstein-Barr virus in pediatric multiple sclerosis [J].
Alotaibi, S ;
Kennedy, J ;
Tellier, R ;
Stephens, D ;
Banwell, B .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (15) :1875-1879
[2]   Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis [J].
Cepok, S ;
Zhou, D ;
Srivastava, R ;
Nessler, S ;
Stei, S ;
Büssow, K ;
Sommer, N ;
Hemmer, B .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (05) :1352-1360
[3]   Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis [J].
Dean, G ;
Elian, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 63 (05) :565-568
[4]   Epstein-Barr virus and multiple sclerosis - Evidence of association from a prospective study with long-term follow-up [J].
DeLorenze, Gerald N. ;
Munger, Kassandra L. ;
Lennette, Evelyn T. ;
Orentreich, Norman ;
Vogelman, Joseph H. ;
Ascherio, Alberto .
ARCHIVES OF NEUROLOGY, 2006, 63 (06) :839-844
[5]   A role of late Epstein-Barr virus infection in multiple sclerosis [J].
Haahr, S ;
Plesner, AM ;
Vestergaard, BF ;
Höllsberg, P .
ACTA NEUROLOGICA SCANDINAVICA, 2004, 109 (04) :270-275
[6]   Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein [J].
Holmoy, T ;
Kvale, EO ;
Vartdal, F .
JOURNAL OF NEUROVIROLOGY, 2004, 10 (05) :278-283
[7]   Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis [J].
Levin, LI ;
Munger, KL ;
Rubertone, MV ;
Peck, CA ;
Lennette, ET ;
Spiegelman, D ;
Ascherio, A .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (20) :2496-2500
[8]   An altered immune response to Epstein-Barr virus in multiple sclerosis -: A prospective study [J].
Sundström, P ;
Juto, P ;
Wadell, G ;
Hallmans, G ;
Svenningsson, A ;
Nyström, L ;
Dillner, J ;
Forsgren, L .
NEUROLOGY, 2004, 62 (12) :2277-2282
[9]   Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis [J].
Thacker, EL ;
Mirzaei, F ;
Ascherio, A .
ANNALS OF NEUROLOGY, 2006, 59 (03) :499-503
[10]   The immune response against herpesvirus is more prominent in the early stages of MS [J].
Villoslada, P ;
Juste, C ;
Tintore, M ;
Llorenç, V ;
Codina, G ;
Pozo-Rosich, P ;
Montalban, X .
NEUROLOGY, 2003, 60 (12) :1944-1948