Migrating colonic crypt epithelial cells: primary targets for transformation

被引：43

作者：

Lamprecht, SA ^{[1
]}

Lipkin, M ^{[1
]}

机构：

[1] Rockefeller Univ, Strang Canc Res Lab, New York, NY 10021 USA

来源：

CARCINOGENESIS | 2002年 / 23卷 / 11期

关键词：

D O I：

10.1093/carcin/23.11.1777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.

引用

页码：1777 / 1780

页数：4

共 71 条

[1] Stem cells: the intestinal stem cell as a paradigm [J].

Bach, SP ;

Renehan, AG ;

Potten, CS .

CARCINOGENESIS, 2000, 21 (03) :469-476

[2] The subcellular destinations of APC proteins [J].

Bienz, M .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (05) :328-338

[3] Gut instincts: thoughts on intestinal epithelial stem cells [J].

Booth, C ;

Potten, CS .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (11) :1493-1499

[4]

BROOKBANK C, 2001, NATURE REV CANC, V1, P2917

[5] Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice [J].

Carothers, AM ;

Melstrom, KA ;

Mueller, JD ;

Weyant, MJ ;

Bertagnolli, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :39094-39102

[6] The cadherin-catenin adhesion system in signaling and cancer [J].

Conacci-Sorrell, M ;

Zhurinsky, J ;

Ben-Ze'ev, A .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (08) :987-991

[7]

DESCHNER EE, 1975, CANCER, V35, P413, DOI 10.1002/1097-0142(197502)35:2<413::AID-CNCR2820350217>3.0.CO

[8]

2-B

[9]

DESCHNER EE, 1974, CANCER, V34, P824, DOI 10.1002/1097-0142(197409)34:3+<824::AID-CNCR2820340707>3.0.CO

[10]

2-2

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