Migrating colonic crypt epithelial cells: primary targets for transformation

被引：43

作者：

Lamprecht, SA ^{[1
]}

Lipkin, M ^{[1
]}

机构：

[1] Rockefeller Univ, Strang Canc Res Lab, New York, NY 10021 USA

来源：

CARCINOGENESIS | 2002年 / 23卷 / 11期

关键词：

D O I：

10.1093/carcin/23.11.1777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.

引用

页码：1777 / 1780

页数：4

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