Pathogen recognition by DC-SIGN shapes adaptive immunity

被引：86

作者：

Geijtenbeek, Teunis B. H. ^{[1
,2
,3
]}

den Dunnen, Jeroen ^{[4
]}

Gringhuis, Sonja I. ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Ctr Infect & Immun Amsterdam, NL-1100 DD Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1100 DD Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MC Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Mol Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

来源：

FUTURE MICROBIOLOGY | 2009年 / 4卷 / 07期

关键词：

adaptive immunity; C-type lectin; DC-SIGN; dendritic cell; HIV-1; innate signaling; Mycobacterium tuberculosis; NF-KAPPA-B; C-TYPE LECTINS; DENDRITIC CELL-FUNCTION; REGULATORY T-CELLS; TOLL-LIKE RECEPTOR-2; MYCOBACTERIUM-TUBERCULOSIS; INNATE IMMUNITY; IN-VITRO; GALACTOSE/N-ACETYLGALACTOSAMINE; ANTIGEN PRESENTATION;

D O I：

10.2217/FMB.09.51

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. This diversity is mediated by cooperation between different pattern recognition receptors that are triggered by specific pathogens, DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition receptor with a broad pathogen recognition specificity as a result of its affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse immune responses to different pathogens, such as bacteria, fungi, helminths and viruses. Recent data show that DC-SIGN triggering by pathogens modulates Toll-like receptor signaling at the level of nuclear factor-kappa B. In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens.

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收藏

页码：879 / 890

页数：12

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