Binding of an inhibitor of the p53/MDM2 interaction to MDM2

被引:57
作者
Duncan, SJ [1 ]
Cooper, MA [1 ]
Williams, DH [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
D O I
10.1039/b211889k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.
引用
收藏
页码:316 / 317
页数:2
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