Homologous repair of DNA damage and tumorigenesis: the BRCA connection

被引：281

作者：

Jasin, M ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

来源：

ONCOGENE | 2002年 / 21卷 / 58期

关键词：

BRCA1; BRCA2; DNA repair; homologous recombination; RAD51;

D O I：

10.1038/sj.onc.1206176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCAJ and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals against tumorigenesis. This review summarizes recent advances in our understanding of BRCA1 and BRCA2 in DNA repair, as well as insight into these proteins gleaned from structure determination of domains of these proteins and the broader evolutionary conservation than previously appreciated.

引用

页码：8981 / 8993

页数：13

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