Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines

被引：93

作者：

Chang, Thomas K. H. ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

来源：

AAPS JOURNAL | 2009年 / 11卷 / 03期

基金：

加拿大健康研究院;

关键词：

constitutive androstane receptor; herbal medicine; pregnane X receptor; ST JOHNS WORT; CYP3A4; GENE-EXPRESSION; TIEN-HSIEN LIQUID; WU-WEI-ZI; NUCLEAR RECEPTORS; GINKGO-BILOBA; NATURAL-PRODUCTS; BIOACTIVE CONSTITUENTS; BILIRUBIN CLEARANCE; DRUG-INTERACTIONS;

D O I：

10.1208/s12248-009-9135-y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation. Ligands of PXR and CAR are chemicals of diverse structures, including naturally occurring compounds present in herbal medicines. The overall aim of this article is to provide an overview of our current understanding of the role of herbal medicines as modulators of PXR and CAR.

引用

页码：590 / 601

页数：12

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