Laying the groundwork for proteomics - Mass spectrometry from 1958 to 1988

被引：23

作者：

Biemann, Klaus ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2007年 / 259卷 / 1-3期

关键词：

mass spectrometry; proteomics; peptide sequencing; protein sequencing; aminoacyl-tRNA synthetases;

D O I：

10.1016/j.ijms.2006.08.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The development of mass spectrometric methodologies for the sequencing of peptides and proteins are recounted. Early strategies for the determination of very large proteins based on a combination of nucleotide sequencing and mass spectrometric amino acid sequencing are described and their historical significance to the new field of proteomics is outlined. Published by Elsevier B.V.

引用

页码：1 / 7

页数：7

共 44 条

[1] FAST ATOM BOMBARDMENT OF SOLIDS (FAB) - A NEW ION-SOURCE FOR MASS-SPECTROMETRY [J].