Orientation of human glioblastoma cells embedded in type I collagen, caused by exposure to a 10 T static magnetic field

被引：32

作者：

Hirose, H

Nakahara, T

Miyakoshi, J

机构：

[1] Hirosaki Univ, Fac Med, Sch Hlth Sci, Dept Radiol Technol, Hirosaki, Aomori 0368564, Japan

[2] Kyoto Univ, Grad Sch Sci, Radiat Biol Lab, Kyoto 6068502, Japan

[3] Mitsubishi Chem Safety Inst Ltd, Kashima Lab, Appl Biol Div, Ibaraki 3140255, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 338卷 / 01期

基金：

日本学术振兴会;

关键词：

static magnetic fields; human glioblastoma A172 cells; type I collagen; microtubules;

D O I：

10.1016/S0304-3940(02)01363-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We investigated the preferred orientation of human glioblastoma cells (A172) following exposure to static magnetic fields (SMF) at 10 Tesla in the presence or absence of collagen. A172 cells embedded in collagen gel were oriented perpendicular to the direction of the SMF. A172 cells cultured in the absence of collagen did not exhibit any specific orientation pattern after 7 days of exposure to the SMF. Thus we succeeded in evoking the magnetic orientation of human glioblastoma cells by exposure to the SMF. Our results suggest that the orientation of glioblastoma cell processes may be due to the arrangement of microtubules under the influence of magnetically oriented collagen fiber. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：88 / 90

页数：3

共 13 条

[1]

Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration [J].