Opioid peptide modulation of circulatory and endocrine response to mental stress in humans

被引：38

作者：

Fontana, F

Bernardi, P

Pich, EM

Boschi, S

DeIasio, R

Spampinato, S

Grossi, G

机构：

[1] GLAXO INST MOL BIOL SA,CH-1228 PLAN LES OUATES,GINEVRA,SWITZERLAND

[2] OSPED S ORSOLA MALPIGHI,SERV FARMACOL CLIN,I-40138 BOLOGNA,ITALY

[3] DEPT FARMACOL,I-40126 BOLOGNA,ITALY

[4] OSPED S ORSOLA MALPIGHI,LAB CENTRALIZZATO,I-40138 BOLOGNA,ITALY

来源：

PEPTIDES | 1997年 / 18卷 / 02期

关键词：

mental arithmetic test; beta-endorphin; dynorphin B; Met-enkephalin; naloxone; catecholamines; atrial natriuretic factor; cortisol; endothelin-1;

D O I：

10.1016/S0196-9781(96)00319-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Healthy subjects were classified according to their percent increase in systolic blood pressure (SBP) after mental arithmetic test (MAT) as low (Delta SBP 9.3-15.1%, n = 15) and high (Delta SBP 35.1-45.4%, n = 15) responders. During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines. Pretreatment with naloxone hydrochloride enhanced (p < 0.01) SEP, heart rate, noradrenaline, cortisol, and endothelin-1 levels, and reduced (p < 0.01) ANF in low responders in response to MAT, whereas it decreased (p < 0.01) hemodynamic parameters, noradrenaline, and endothelin-1 in high responders. The individual differences in hemodynamic and endocrine responses to MAT may depend on a different activation of the endogenous opioid. system. (C) 1997 Elsevier Science Inc.

引用

页码：169 / 175

页数：7