Stem cells, microenvironment mechanics, and growth factor activation

被引：82

作者：

Tenney, Rebeca M. ^{[1
]}

Discher, Dennis E. ^{[1
]}

机构：

[1] Univ Penn, Cell & Mol Biol CAMB Grad Grp, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 05期

关键词：

EXTRACELLULAR-MATRIX PROTEINS; MARROW STROMAL CELLS; TGF-BETA; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; SIGNALING PATHWAYS; LATENT TGF-BETA-1; GENE-EXPRESSION; IN-VITRO; FIBRONECTIN;

D O I：

10.1016/j.ceb.2009.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Physicochemical features of a cell's microenvironment can exert important effects on cell behavior and include the effects of matrix elasticity on cell differentiation processes, but molecular mechanisms are largely mysterious. Here we highlight recent reports of a mechanical dependence to growth factor activation, with a particular focus on release of TGF beta (Transforming Growth Factor beta) from its large latent complex via forced unfolding. We discuss these processes and pathways in the contexts of matrix adhesion and fluid shearing as they might relate to stem cell differentiation and other mechanisms in development, disease, and repair.

引用

页码：630 / 635

页数：6

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