On estimating the heterozygosity and polymorphism information content value

被引：182

作者：

Shete, S ^{[1
]}

Tiwari, H ^{[1
]}

Elston, RC ^{[1
]}

机构：

[1] Case Western Reserve Univ, Rammelkamp Ctr Educ & Res, Dept Epidemiol & Biostat, Cleveland, OH 44109 USA

来源：

THEORETICAL POPULATION BIOLOGY | 2000年 / 57卷 / 03期

关键词：

polymorphism information content; uniformly minimum variance unbiased estimator; maximum likelihood estimator; multinomial distribution; heterozygosity;

D O I：

10.1006/tpbi.2000.1452

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 [生物信息与计算生物学]; 0713 [生态学];

摘要：

The polymorphism information content (PIC) value is commonly used in genetics as a measure of polymorphism for a marker locus used in linkage analysis. In this communication we have derived the uniformly minimum variance unbiased estimator of PIC along with its exact variance. We have also calculated the exact variance of the maximum likelihood estimator of PIC which is asymptotically an unbiased estimator. In order to find this variance we have derived a recursive formula to calculate the moments of any polynomial in a set of variables that are multinomially distributed. (C) 2000 academic Press.

引用

页码：265 / 271

页数：7