Preparation of 4-heteroaryl-4-cyanopiperidines via SNAr substitution reactions

被引：13

作者：

Chang, Ronald K. ^{[1
]}

Di Marco, Christina N. ^{[1
]}

Pitts, Daniel R. ^{[1
]}

Greshock, Thomas J. ^{[1
]}

Kuduk, Scott D. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 46期

关键词：

ALPHA-ARYLATION; NITRILES;

D O I：

10.1016/j.tetlet.2009.08.123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The scope and limitations of SNAr substitution reactions of metalated 4-cyanopiperidines with heterocyclic halides were explored. These facile reactions provide rapid access to a wide range of 4-heteroaryl-4-cyanopiperidines and have resulted in improved yields, faster reaction times, and lower temperatures than previously published synthetic methods. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6303 / 6306

页数：4

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