Effect of diabetes on lower urinary tract symptoms in patients with benign prostatic hyperplasia

被引:137
作者
Michel, MC
Mehlburger, L
Schumacher, H
Bressel, HU
Goepel, M
机构
[1] Univ Essen Gesamthsch, Dept Med, D-4300 Essen, Germany
[2] Univ Essen Gesamthsch, Dept Urol, D-4300 Essen, Germany
[3] Boehringer Ingelheim, Ingelheim, Germany
[4] Yamanouchi Pharma, Heidelberg, Germany
关键词
age; prostatic hyperplasia; diabetes mellitus;
D O I
10.1016/S0022-5347(05)67529-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Several studies have suggested a specific association between the presence and/or symptom intensity of benign prostatic hyperplasia (BPH) and diabetes but to our knowledge no definitive conclusion has been reached. Therefore, we examined the intensity of lower urinary tract symptoms in a large cohort of men with BPH with and without diabetes. We then determined whether the alpha 1-adrenoceptor antagonist tamsulosin similarly improved lower urinary tract symptoms in patients with BPH with or without diabetes. Materials and Methods: The International Prostate Symptom Score (T-PSS), maximum flow rate and post-void residual were determined in 9,856 men with clinically diagnosed BPH, of whom 1,290 also had diabetes, at baseline and after a 12 week, open label course of 0.4 mg. tamsulosin daily. Results: Logistic regression of the baseline data indicated that older age and I-PSS were independently associated with a statistically significant increase in the odds ratio of having diabetes. Accordingly, diabetics had a significantly greater baseline I-PSS and smaller maximum flow rate than non-diabetic patients on age-adjusted analysis, while residual urine was not significantly altered. Tamsulosin markedly improved lower urinary tract symptoms. The extent of improvement was similar in diabetic and nondiabetic patients, although some slight differences reached statistical significance due to large patient numbers. Conclusions: The severity of lower urinary tract symptoms in patients with BPH and the likelihood of having diabetes are significantly associated. Within the limitations of an open label, observational study tamsulosin appears to reduce lower urinary tract symptoms similarly in patients with BPH with or without diabetes.
引用
收藏
页码:1725 / 1729
页数:5
相关论文
共 22 条
[11]   NATURAL-HISTORY OF PROSTATISM - RELATIONSHIP AMONG SYMPTOMS, PROSTATE VOLUME AND PEAK URINARY FLOW-RATE [J].
GIRMAN, CJ ;
JACOBSEN, SJ ;
GUESS, HA ;
OESTERLING, JE ;
CHUTE, CG ;
PANSER, LA ;
LIEBER, MM .
JOURNAL OF UROLOGY, 1995, 153 (05) :1510-1515
[12]  
GLYNN RJ, 1985, AM J EPIDEMIOL, V121, P78
[13]   DIABETES MELLITUS AND PROSTATIC HYPERPLASIA [J].
LAKE, B ;
BOURKE, JB ;
GRIFFIN, JP .
BMJ-BRITISH MEDICAL JOURNAL, 1968, 4 (5634) :832-+
[14]   The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia [J].
Lepor, H ;
Williford, WO ;
Barry, MJ ;
Brawer, MK ;
Dixon, CM ;
Gormley, G ;
Haakenson, C ;
Machi, M ;
Narayan, P ;
Padley, RJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (08) :533-539
[15]   Phase III multicenter placebo-controlled study of tamsulosin in benign prostatic hyperplasia [J].
Lepor, H .
UROLOGY, 1998, 51 (06) :892-900
[16]   Prospective study of men with clinical benign prostatic hyperplasia treated with alfuzosin by general practitioners: 1-year results [J].
Lukacs, B ;
Leplege, A ;
Thibault, P ;
Jardin, A .
UROLOGY, 1996, 48 (05) :731-740
[17]   Age related urodynamic changes in patients with benign prostatic hyperplasia [J].
Madersbacher, S ;
Klingler, HC ;
Schatzl, G ;
Stulnig, T ;
Schmidbauer, CP ;
Marberger, M .
JOURNAL OF UROLOGY, 1996, 156 (05) :1662-1667
[18]   Tamsulosin treatment of 19,365 patients with lower urinary tract symptoms:: Does co-morbidity alter tolerability? [J].
Michel, MC ;
Mehlburger, L ;
Bressel, HU ;
Schumacher, H ;
Schäfers, RF ;
Goepel, M .
JOURNAL OF UROLOGY, 1998, 160 (03) :784-791
[19]  
Ozturk Y, 1996, PHARMACOL REV, V48, P69