Synthetic study of 4-substituted piperidine ring in elarofiban, RWJ-50042, tirofiban and paroxetine

被引：14

作者：

Chang, MY

Lin, JYC

Chen, ST ^{[1
]}

Chang, NC

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2002年 / 49卷 / 06期

关键词：

piperidine; glutarimide; elarofiban; RWJ-50042; tirofiban; paroxetine; femoxetine;

D O I：

10.1002/jccs.200200156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for synthesizing a 4-substituted piperidine ring uses the formal [3+3] cycloaddition reaction as the key protocol. This method provides a convenient formal synthesis of elarofiban, RWJ-50042, tirofiban and paroxetine.

引用

页码：1079 / 1088

页数：10

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