Cancer after nuclear fallout: lessons from the Chernobyl accident

被引：102

作者：

Williams, D ^{[1
]}

机构：

[1] Strangeways Res Lab, Thyroid Carcinogenesis Res Grp, Cambridge CB1 8RN, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrc845

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Chernobyl accident exposed people located hundreds of kilometres away tofallout, but increases in cancer incidence asa result of the accident seem, at present, tobe restricted to one tumour type. Thesethyroid tumours form the largest number ofcancers of one type, caused by a singleevent on one date, ever recorded.Epidemiological, pathological and molecularstudies have provided new insights into thecarcinogenic process, as well as lessons forfuture nuclear accidents. © 2002 Nature Publishing Group.

引用

页码：543 / 549

页数：7

共 53 条

[1]

[Anonymous], 1997, EST EXP THYR DOS REC

[2] Chernobyl-related thyroid cancer in children of Belarus: A case-control study [J].

Astakhova, LN ;

Anspaugh, LR ;

Beebe, GW ;

Bouville, A ;

Drozdovitch, VV ;

Garber, V ;

Gavrilin, YI ;

Khrouch, VT ;

Kuvshinnikov, AV ;

Kuzmenkov, YN ;

Minenko, VP ;

Moschik, KV ;

Nalivko, AS ;

Robbins, J ;

Shemiakina, EV ;

Shinkarev, S ;

Tochitskaya, SI ;

Waclawiw, MA .

RADIATION RESEARCH, 1998, 150 (03) :349-356

[3] Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma [J].

Basolo, F ;

Giannini, R ;

Monaco, C ;

Melillo, RM ;

Carlomagno, F ;

Pancrazi, M ;

Salvatore, G ;

Chiappetta, G ;

Pacini, F ;

Elisei, R ;

Miccoli, P ;

Pinchera, A ;

Fusco, A ;

Santoro, M .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (01) :247-254

[4]

BAVERSTOCK K, 1992, NATURE, V359, P21, DOI 10.1038/359021b0

[5] Familial nontoxic multinodular thyroid goiter locus maps to chromosome 149 but does not account for familial nonmedullary thyroid cancer [J].

Bignell, GR ;

Canzian, F ;

Shayeghi, M ;

Stark, M ;

Shugart, YY ;

Biggs, P ;

Mangion, J ;

Hamoudi, R ;

Rosenblatt, J ;

Buu, P ;

Sun, S ;

Stoffer, SS ;

Goldgar, DE ;

Romeo, G ;

Houlston, RS ;

Narod, SA ;

Stratton, MR ;

Foulkes, WD .

AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (05) :1123-1130

[6] MOLECULAR CHARACTERIZATION OF A THYROID TUMOR-SPECIFIC TRANSFORMING SEQUENCE FORMED BY THE FUSION OF RET TYROSINE KINASE AND THE REGULATORY SUBUNIT RI-ALPHA OF CYCLIC AMP-DEPENDENT PROTEIN KINASE-A [J].

BONGARZONE, I ;

MONZINI, N ;

BORRELLO, MG ;

CARCANO, C ;

FERRARESI, G ;

ARIGHI, E ;

MONDELLINI, P ;

DELLAPORTA, G ;

PIEROTTI, MA .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (01) :358-366

[7]

Braverman L.E., 1991, THYROID FUNDAMENTAL

[8] A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2 [J].

Canzian, F ;

Amati, P ;

Harach, HR ;

Kraimps, JL ;

Lesueur, F ;

Barbier, J ;

Levillain, P ;

Romeo, G ;

Bonneau, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (06) :1743-1748

[9]

CARDIS E, 1999, RAD THYROID CANC

[10]

DEMIDCHIK EP, 1999, RAD THYROID CANC, P51

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