Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling

被引：39

作者：

Chiba, T ^{[1
]}

Yamaza, H ^{[1
]}

Higami, Y ^{[1
]}

Shimokawa, I ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Resp & Digest Med, Div Expt Med Pathol & Gerontol, Nagasaki 8528523, Japan

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 2002年 / 59卷 / 04期

关键词：

leptin; insulin; ghrelin; adipocytokine; IGF-I;

D O I：

10.1002/jemt.10211

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Many hormonal signals from peripheral tissues contribute to the regulation of energy homeostasis and food intake. These regulators including leptin, insulin, and ghrelin, modulate the orexigenic and anorexigenic neuropeptide expression in hypothalamic nuclei. The anti-aging effects of caloric restriction have been explained from an evolutional viewpoint of the adaptive response of the neuroendocrine and metabolic response systems to maximize survival during periods of food shortage. In organisms, excess energy is stored in adipose tissues as a triglyceride preparation for such survival situations. Adipose tissue has recently been recognized as an endocrine organ, and leptin, as secreted by adipocyte, seems to be an especially important factor for the adaptive response to fasting and neuroendocrine alterations under caloric restriction. In this review, we discuss the potential involvement of neuroendocrine modulators in longevity and the anti-aging effects of caloric restriction. (C) 2002 Wiley-Liss, Inc.

引用

页码：317 / 324

页数：8

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