Sensing RNA virus infections

被引：12

作者：

Basler, Christopher F. ^{[1
]}

Garcia-Sastre, Adolfo ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 01期

关键词：

D O I：

10.1038/nchembio0107-20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RIG-I is an RNA helicase that senses viral infections and triggers innate and adaptive immune mechanisms. Recent studies have identified RNAs bearing 5'-triphosphates as ligands of RIG-I and have suggested a mechanism for how RIG-I distinguishes viral RNA from host RNA.

引用

页码：20 / 21

页数：3

共 11 条

[1] Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems [J].

García-Sastre, A ;

Egorov, A ;

Matassov, D ;

Brandt, S ;

Levy, DE ;

Durbin, JE ;

Palese, P ;

Muster, T .

VIROLOGY, 1998, 252 (02) :324-330

[2] Type 1 interferons and the virus-host relationship:: A lesson in detente [J].

García-Sastre, A ;

Biron, CA .

SCIENCE, 2006, 312 (5775) :879-882

[3] NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I [J].

Guo, Zhu ;

Chen, Li-mei ;

Zeng, Hui ;

Gomez, Jorge A. ;

Plowden, Julie ;

Fujita, Takashi ;

Katz, Jacqueline M. ;

Donis, Ruben O. ;

Sambhara, Suryaprakash .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2007, 36 (03) :263-269

[4] 5′-triphosphate RNA is the ligand for RIG-I [J].

Hornung, Veit ;

Ellegast, Jana ;

Kim, Sarah ;

Brzozka, Krzysztof ;

Jung, Andreas ;

Kato, Hiroki ;

Poeck, Hendrik ;

Akira, Shizuo ;

Conzelmann, Karl-Klaus ;

Schlee, Martin ;

Endres, Stefan ;

Hartmann, Gunther .

SCIENCE, 2006, 314 (5801) :994-997

[5] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses [J].

Kato, H ;

Takeuchi, O ;

Sato, S ;

Yoneyama, M ;

Yamamoto, M ;

Matsui, K ;

Uematsu, S ;

Jung, A ;

Kawai, T ;

Ishii, KJ ;

Yamaguchi, O ;

Otsu, K ;

Tsujimura, T ;

Koh, CS ;

Sousa, CRE ;

Matsuura, Y ;

Fujita, T ;

Akira, S .

NATURE, 2006, 441 (7089) :101-105

[6] TLR signaling [J].

Kawai, T ;

Akira, S .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (05) :816-825

[7] Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza a virus [J].

Mibayashi, Masaki ;

Martinez-Sobrido, Luis ;

Loo, Yueh-Ming ;

Cardenas, Washington B. ;

Gale, Michael, Jr. ;

Garcia-Sastre, Adolfo .

JOURNAL OF VIROLOGY, 2007, 81 (02) :514-524

[8] RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates [J].

Pichlmair, Andreas ;

Schulz, Oliver ;

Tan, Choon Ping ;

Naslund, Tanja I. ;

Liljestrom, Peter ;

Weber, Friedemann ;

Sousa, Caetano Reis E. .

SCIENCE, 2006, 314 (5801) :997-1001

[9] Activation of TBK1 and IKKε kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity [J].

tenOever, BR ;

Sharma, S ;

Zou, W ;

Sun, Q ;

Grandvaux, N ;

Julkunen, I ;

Hemmi, H ;

Yamamoto, M ;

Akira, S ;

Yeh, WC ;

Lin, RT ;

Hiscott, J .

JOURNAL OF VIROLOGY, 2004, 78 (19) :10636-10649

[10] Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses [J].

Weber, Friedemann ;

Wagner, Valentina ;

Rasmussen, Simon B. ;

Hartmann, Rune ;

Paludan, Soren R. .

JOURNAL OF VIROLOGY, 2006, 80 (10) :5059-5064

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