Novel drug interactions at D2 dopamine receptors:: Modulation of [3H]quinpirole binding by monoamine oxidase inhibitors

被引：14

作者：

Levant, B ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA

来源：

LIFE SCIENCES | 2002年 / 71卷 / 23期

关键词：

D-2 dopamine receptor; quinpirole; monoamine oxidase inhibitor;

D O I：

10.1016/S0024-3205(02)02109-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

D-2 dopamine receptors are the principal target of drugs used to treat schizophrenia and Parkinson's disease. Recent findings suggest novel drug interactions at D-2 receptors, specifically interactions of monoamine oxidase inhibitors (MAOIs) at a novel binding site that modulates the binding of [H-3]quinpirole to the D-2 receptor. That MAOIs inhibit [H-3]quinpirole binding challenges the traditional understanding of ligand interactions at dopamine receptors and may shed light on the mechanism of behavioral sensitization to psychostimulants and the pharmacology and toxicity of MAOIs. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：2691 / 2700

页数：10

共 56 条

[51] Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control [J].