Autonomously-triggered microfluidic cooling using thermo-responsive hydrogels

被引:34
作者
Agarwal, Abhishek K.
Dong, Liang
Beebe, David J.
Jiang, Hongrui
机构
[1] Univ Wisconsin, Dept Elect & Comp Engn, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA
关键词
D O I
10.1039/b617767k
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present autonomously-triggered on-chip microfluidic cooling devices that utilize thermoresponsive hydrogels to adapt to local environmental temperatures. An external rotating magnetic stirrer couples with an in situ fabricated nickel impeller in these centrifugal-based microfluidic cooling devices to recirculate cooler water. Temperature-responsive hydrogels, which exhibit volumetric expansion and contraction, are integrated at the axle of the impeller. In this design, the hydrogels behave similar to an automotive clutch, to autonomously control the impeller's rotation as a function of the local environmental temperature. Therefore, the hydrogels act as both sensors and actuators and help take away the necessity for additional temperature sensing, feedback, and/or control units here. Cooling devices capable of on-chip thermal management at multiple predetermined onset operation points are realized by changes to the composition of hydrogel to alter its lowest critical solution temperature (LCST). Furthermore, the effect of magnetic stirrer frequency on the fluid cooling and flowrates for different two-blade nickel impeller designs are presented.
引用
收藏
页码:310 / 315
页数:6
相关论文
共 24 条
[11]  
Liu J, 2002, ELECTROPHORESIS, V23, P1531, DOI 10.1002/1522-2683(200205)23:10<1531::AID-ELPS1531>3.0.CO
[12]  
2-D
[13]   Thermal management in microfluidics using micro-Peltier junctions [J].
Maltezos, G ;
Johnston, M ;
Scherer, A .
APPLIED PHYSICS LETTERS, 2005, 87 (15) :1-3
[14]   Polymer gels (Reprinted from Functional Monomers and Polymers, pg 497-528, 1997) [J].
Osada, Y ;
Gong, JP ;
Tanaka, Y .
JOURNAL OF MACROMOLECULAR SCIENCE-POLYMER REVIEWS, 2004, C44 (01) :87-112
[15]   Electronically controllable microvalves based on smart hydrogels: Magnitudes and potential applications [J].
Richter, A ;
Kuckling, D ;
Howitz, S ;
Gehring, T ;
Arndt, KF .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2003, 12 (05) :748-753
[16]   Thermal management of BioMEMS: Temperature control for ceramic-based PCR and DNA detection devices [J].
Sadler, DJ ;
Changrani, R ;
Roberts, P ;
Chou, CF ;
Zenhausern, F .
IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TECHNOLOGIES, 2003, 26 (02) :309-316
[17]   Thermal properties of copolymer gels containing N-isopropylacrylamide [J].
Shibayama, M ;
Mizutani, S ;
Nomura, S .
MACROMOLECULES, 1996, 29 (06) :2019-2024
[18]   Microfluidic device for airborne BTEX detection [J].
Ueno, Y ;
Horiuchi, T ;
Morimoto, T ;
Niwa, O .
ANALYTICAL CHEMISTRY, 2001, 73 (19) :4688-4693
[19]  
van der Linden H, 2004, LAB CHIP, V4, P619, DOI 10.1039/b406247g
[20]  
WILDING P, 1995, CLIN CHEM, V41, P1367