Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

被引：53

作者：

Wang, WY

Préville, P

Morin, N

Mounir, S

Cai, WZ

Siddiqui, MA

机构：

[1] BioChem Pharma Inc, Laval, PQ H7V 4A7, Canada

[2] OSI Pharmaceut Inc, Uniondale, NY 11553 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00217-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine kit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：1151 / 1154

页数：4

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