Boronated DNA-binding compounds as potential agents for boron neutron capture therapy

被引：65

作者：

Crossley, Ellen L.

Ziolkowski, Erin J.

Coderre, Jeffrey A.

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 03期

关键词：

boron neutron capture therapy; boronated agent; carborane; DNA-targeting; boronic acid;

D O I：

10.2174/138955707780059808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive B-10 nucleus and low-energy (thermal) neutrons for the destruction of turnout cells. If boronated agents are targeted towards chromosomal DNA. the efficiency of BNcT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

引用

页码：303 / 313

页数：11

共 79 条

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