Boronated DNA-binding compounds as potential agents for boron neutron capture therapy

被引：65

作者：

Crossley, Ellen L.

Ziolkowski, Erin J.

Coderre, Jeffrey A.

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 03期

关键词：

boron neutron capture therapy; boronated agent; carborane; DNA-targeting; boronic acid;

D O I：

10.2174/138955707780059808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive B-10 nucleus and low-energy (thermal) neutrons for the destruction of turnout cells. If boronated agents are targeted towards chromosomal DNA. the efficiency of BNcT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

引用

收藏

页码：303 / 313

页数：11

相关论文

共 79 条

[41] Interactions of anionic carboranylated porphyrins with DNA [J].

Lauceri, R ;

Purrello, R ;

Shetty, SJ ;

Vicente, MGH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (24) :5835-5836

[42] Boron clusters - A new entity for DNA-oligonucleotide modification [J].

Lesnikowski, ZJ .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (23) :4489-4500

[43] Nucleic acids and nucleosides containing carboranes [J].

Lesnikowski, ZJ ;

Shi, JX ;

Schinazi, RF .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1999, 581 (1-2) :156-169

[44]

Locher GL, 1936, AM J ROENTGENOL RADI, V36, P1

[45] N-benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging:: Synthesis and biological evaluation [J].

Martin, B ;

Possémé, F ;

Le Barbier, C ;

Carreaux, F ;

Carboni, B ;

Seiler, N ;

Moulinoux, JP ;

Delcros, JG .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (22) :3653-3664

[46] INDUCTION OF DOUBLE-STRAND BREAKS FOLLOWING NEUTRON-CAPTURE BY DNA-BOUND GD-157 [J].

MARTIN, RF ;

DCUNHA, G ;

PARDEE, M ;

ALLEN, BJ .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 54 (02) :205-208

[47] INDUCTION OF DNA DOUBLE-STRAND BREAKS BY GD-157 NEUTRON-CAPTURE [J].

MARTIN, RF ;

DCUNHA, G ;

PARDEE, M ;

ALLEN, BJ .

PIGMENT CELL RESEARCH, 1989, 2 (04) :330-332

[48]

Miura M, 2001, RADIAT RES, V155, P603, DOI 10.1667/0033-7587(2001)155[0603:BNCTOA]2.0.CO

[49]

2

[50] Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages [J].

Miyatake, SI ;

Kawabata, S ;

Kajimoto, Y ;

Aoki, AH ;

Yokoyama, K ;

Yamada, M ;

Kuroiwa, T ;

Tsuji, M ;

Imahori, Y ;

Kirihata, M ;

Sakurai, Y ;

Masunaga, SI ;

Nagata, K ;

Maruhashi, A ;

Ono, K .

JOURNAL OF NEUROSURGERY, 2005, 103 (06) :1000-1009

← 1 2 3 4 5 6 7 8 →