Modelling human diseases in Drosophila and Caenorhabditis

被引：45

作者：

O'Kane, CJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

mutagenesis; genetic screens; model organisms; insulin; dopamine;

D O I：

10.1016/S1084-9521(02)00162-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drosophila (fruitfly) and Caenorhabditis (nematode worm) are useful model organisms for understanding many molecular and cellular mechanisms of human disease. Work on them is powered by versatile gene discovery methods, output of their genome projects, and a biology that has much in common with that of humans. They contain homologues of most human disease genes. Many aspects of human disease, and of defences against disease, are also found in flies and worms. These include cancer, ageing, neurodegeneration, infectious disease, innate immunity, and dysfunction of neurotransmitter and endocrine systems. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3 / 10

页数：8

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