microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases

被引：100

作者：

Christensen, Mette ^{[1
,2
,3
]}

Schratt, Gerhard M. ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Jr Grp SFB488, Interdisziplinares Zentrum Neurowissensch, D-69120 Heidelberg, Germany

[2] Univ Klinikum Heidelberg, Inst Neuroanat, D-69120 Heidelberg, Germany

[3] Univ Copenhagen, Panum Inst, Dept Cellular & Mol Med, Wilhelm Johannsen Ctr Funct Genome Res, DK-2200 Copenhagen N, Denmark

来源：

NEUROSCIENCE LETTERS | 2009年 / 466卷 / 02期

基金：

英国医学研究理事会;

关键词：

microRNAs; Nervous system; Differentiation; Plasticity; Neurological diseases; MENTAL-RETARDATION PROTEIN; AMYLOID PRECURSOR PROTEIN; NEURONAL DIFFERENTIATION; MICROARRAY ANALYSIS; ALZHEIMERS-DISEASE; LET-7; MICRORNA; EXPRESSION; BRAIN; RNA; MIR-124;

D O I：

10.1016/j.neulet.2009.04.043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

microRNAs, small non-coding RNAs that regulate gene expression at the post-transcriptional level, are emerging as important regulatory molecules involved in the fine-tuning of gene expression during neuronal development and function. microRNAs have roles during neuronal stem cell commitment and early differentiation as well as in later stages of neuronal development, such as dendritogenesis and synaptic plasticity. A link between microRNAs and neurological diseases, such as neurodegeneration or synaptic dysfunction, is becoming increasingly clear. This review summarizes the current knowledge of the function of microRNAs in the developing and adult nervous system and their potential contribution to the etiology of neurological diseases. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：55 / 62

页数：8

共 77 条

[1] Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].