Cytokines and chemokines shaping the B-cell compartment

被引:30
作者
Acosta-Rodriguez, Eva V. [1 ]
Merino, Maria C. [1 ]
Montes, Carolina L. [1 ]
Cristina Motran, C. [1 ]
Gruppi, Adriana [1 ]
机构
[1] Natl Univ Cordoba, Sch Chem Sci, Dept Clin Biochem, Cordoba, Argentina
关键词
B-cell; lymphocyte development; lymphocyte compartmentalization; humoral response;
D O I
10.1016/j.cytogfr.2007.01.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:73 / 83
页数:11
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