Cytokines and chemokines shaping the B-cell compartment

被引：30

作者：

Acosta-Rodriguez, Eva V. ^{[1
]}

Merino, Maria C. ^{[1
]}

Montes, Carolina L. ^{[1
]}

Cristina Motran, C. ^{[1
]}

Gruppi, Adriana ^{[1
]}

机构：

[1] Natl Univ Cordoba, Sch Chem Sci, Dept Clin Biochem, Cordoba, Argentina

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 1-2期

关键词：

B-cell; lymphocyte development; lymphocyte compartmentalization; humoral response;

D O I：

10.1016/j.cytogfr.2007.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：73 / 83

页数：11

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