Cell biology - GTPase traffic control

被引：10

作者：

Der, CJ ^{[1
]}

Balch, WE

机构：

[1] Univ N Carolina, Dept Pharmacol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

NATURE | 2000年 / 405卷 / 6788期

关键词：

D O I：

10.1038/35015654

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cdc42 is a small GTPase that interacts with various downstream targets to regulate many cellular processes. The latest target to be identified is a subunit of a complex involved in vesicle formation. Surprisingly, this subunit may be required for Cdc42 to induce cells to switch to malignant growth.

引用

页码：749 / 752

页数：3

共 9 条

[1] Cell biology - Protein sorting by directed maturation of Golgi compartments
Allan, RB
Balch, WE
[J]. SCIENCE, 1999, 285 (5424) : 63 - 66
[2] Regulation of endocytic traffic by Rho family GTPases
Ellis, S
Mellor, H
[J]. TRENDS IN CELL BIOLOGY, 2000, 10 (03) : 85 - 88
[3] Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
Erickson, JW
Zhang, CJ
Kahn, RA
Evans, T
Cerione, RA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (43) : 26850 - 26854
[4] Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex
Goldberg, J
[J]. CELL, 2000, 100 (06) : 671 - 679
[5] Novel Cdc42Hs mutant induces cellular transformation
Lin, R
Bagrodia, S
Cerione, R
Manor, D
[J]. CURRENT BIOLOGY, 1997, 7 (10) : 794 - 797
[6] Regulation of membrane traffic in animal cells by COPI
Lowe, M
Kreis, TE
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1998, 1404 (1-2): : 53 - 66
[7] Rho GTPases and signaling networks
VanAelst, L
D'Souza-Schorey, C
[J]. GENES & DEVELOPMENT, 1997, 11 (18) : 2295 - 2322
[8] The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation
Wu, WJ
Erickson, JW
Lin, R
Cerione, RA
[J]. NATURE, 2000, 405 (6788) : 800 - 804
[9] Rho family proteins and Ras transformation: the RHOad less traveled gets congested
Zohn, IM
Campbell, SL
Khosravi-Far, R
Rossman, KL
Der, CJ
[J]. ONCOGENE, 1998, 17 (11) : 1415 - 1438

← 1 →