Detection of HPV-16 DNA by PCR in histologically cancer free lymph nodes from patients with cervical cancer

被引：25

作者：

Baay, MFD

Koudstaal, J

Hollema, H

Duk, JM

Burger, MPM

Quint, WGV

Stolz, E

Herbrink, P

机构：

[1] SSDZ,DEPT IMMUNOL & INFECT DIS,CTR DIAGNOST,NL-2500 GA DELFT,NETHERLANDS

[2] SSDZ,DEPT BIOL MOL,CTR DIAGNOST,NL-2500 GA DELFT,NETHERLANDS

[3] UNIV AMSTERDAM,ACAD MED CTR,DIV OBSTET & GYNAECOL,NL-1105 AZ AMSTERDAM,NETHERLANDS

[4] UNIV AMSTERDAM,ACAD MED CTR,DEPT OBSTET & GYNAECOL,NL-1105 AZ AMSTERDAM,NETHERLANDS

[5] UNIV GRONINGEN HOSP,DEPT PATHOL,GRONINGEN,NETHERLANDS

[6] ERASMUS UNIV ROTTERDAM,DEPT DERMATOVENEREOL,ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1997年 / 50卷 / 11期

关键词：

human papillomavirus; cervical cancer; lymph nodes; prognosis; polymerase chain reaction;

D O I：

10.1136/jcp.50.11.960

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The prognostic value of detection of human papillomavirus (HPV) type 16 DNA in histologically cancer free lymph nodes was assessed in left obturator lymph nodes from cervical cancer patients with HPV-16 positive primary tumours. HPV-16 DNA was detected by polymerase chain reaction in 12 of 35 patients with histologically cancer free lymph nodes. Of these 12 patients, only one developed a recurrence, suggesting HPV-16 DNA detection in cancer free lymph nodes has no prognostic value.

引用

页码：960 / 961

页数：2

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