Studies towards total synthesis of antillatoxin: Indium-mediated allylation reaction of carbonyl compounds with secondary allylic bromide in aqueous media

被引：13

作者：

Loh, TP ^{[1
]}

Song, HY ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

SYNLETT | 2002年 / 12期

关键词：

antillatoxin; homoallylic alcohols; indium; allylation reaction; aqueous media;

D O I：

10.1055/s-2002-35606

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have established a new reaction condition for the indium-mediated allylation of an unreactive secondary allylic bromide with aldehydes in aqueous media to afford the corresponding homoallylic alcohols in high yields and syn diastereoselectivity. Furthermore, it has provided an easy entry to the key intermediate for the total synthesis of antillatoxin under mild and environment profitable conditions.

引用

页码：2119 / 2121

页数：3

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