Variability in responsiveness to irritants: thoughts on possible underlying mechanisms

被引：13

作者：

Willis, CM ^{[1
]}

机构：

[1] Amersham Hosp, Dept Dermatol, Amersham HP7 0JD, Bucks, England

来源：

CONTACT DERMATITIS | 2002年 / 47卷 / 05期

关键词：

atopy; gene polymorphism; interleukin-1; irritant contact dermatitis; susceptibility; tumor necrosis factor;

D O I：

10.1034/j.1600-0536.2002.470503.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Patch testing with chemical irritants almost always produces a striking variability in the intensity of reaction between individuals, even amongst normal, healthy subjects. Whilst there have been many attempts to define factors which predispose to heightened or, conversely, to diminished reactivity, the underlying cellular mechanisms responsible for the variability remain poorly understood. In this review, a number of possible explanations are proposed, with a particular emphasis on those which relate to the influence of pre-existing disease or to the genetic regulation of certain immunological and inflammatory processes.

引用

页码：267 / 271

页数：5

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