Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity

被引：50

作者：

Wang, Lijian ^{[3
]}

Cherayil, Bobby J. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Pediat Gastroenterol Unit, Mucosal Immunol Lab, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 05期

关键词：

Iron homeostasis; Macrophage; Inflammation; NF-KAPPA-B; SLC11A1 FORMERLY NRAMP1; TRANSCRIPTIONAL REGULATION; PATHOGEN INTERACTIONS; HEPCIDIN EXPRESSION; EPITHELIAL-CELLS; HEME OXYGENASE-1; PROTEIN; MICE; HEMOCHROMATOSIS;

D O I：

10.1159/000210016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Iron is an essential micronutrient for both microbial pathogens and their mammalian hosts. Changes in iron availability and distribution have significant effects on pathogen virulence and on the immune response to infection. Recent advances in our understanding of the molecular regulation of iron metabolism have shed new light on how alterations in iron homeostasis both contribute to and influence innate immunity. In this article, we review what is currently known about the role of iron in the response to infection. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：455 / 464

页数：10

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