Nramp1 phagocyte intracellular metal withdrawal defense

被引：147

作者：

Cellier, Mathieu F. ^{[1
]}

Courville, Pascal ^{[1
]}

Campion, Carole ^{[1
]}

机构：

[1] Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 14-15期

基金：

加拿大自然科学与工程研究理事会;

关键词：

divalent cations; transport proteins; phagosomes;

D O I：

10.1016/j.micinf.2007.09.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1662 / 1670

页数：9

共 60 条

[1] Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids [J].

Ali, A ;

Zhang, Q ;

Dai, JS ;

Huang, X .

BIOMETALS, 2003, 16 (02) :285-293

[2]

Barrera LF, 2004, MOL B INT U, P44

[3] The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling [J].

Berra, E ;

Ginouvès, A ;

Pouysségur, J .

EMBO REPORTS, 2006, 7 (01) :41-45

[4]

Blackwell JM, 2004, MOL B INT U, P53

[5] The effect of the host's iron status on tuberculosis [J].

Boelaert, Johan R. ;

Vandecasteele, Stefaan J. ;

Appelberg, Rui ;

Gordeuk, Victor R. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (12) :1745-1753

[6] Mycobacterium-inducible Nramp in striped bass (Morone saxatilis) [J].

Burge, EJ ;

Gauthier, DT ;

Ottinger, CA ;

Van Veld, PA .

INFECTION AND IMMUNITY, 2004, 72 (03) :1626-1636

[7]

Canonne-Hergaux F, 2004, MOL B INT U, P96

[8] Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo [J].

Chaloupka, R ;

Courville, P ;

Veyrier, F ;

Knudsen, B ;

Tompkins, TA ;

Cellier, MFM .

BIOCHEMISTRY, 2005, 44 (02) :726-733

[9] NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1 [J].

Cheah, Jaime H. ;

Kim, Sangwon F. ;

Hester, Lynda D. ;

Clancy, Kathleen W. ;

Patterson, Stanley E., III ;

Papadopoulos, Vassilios ;

Snyder, Solomon H. .

NEURON, 2006, 51 (04) :431-440

[10] Molecular cloning, characterization and expression analysis of natural resistance associated macrophage protein (Nramp) cDNA from turbot (Scophthalmus maximus) [J].

Chen, Song-Lin ;

Zhang, Yu-Xi ;

Xu, Jian-Yong ;

Meng, Liang ;

Sha, Zhen-Xia ;

Ren, Guo-Cheng .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2007, 147 (01) :29-37

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