Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from Vitex trifolia

被引：71

作者：

Alam, G

Wahyuono, S

Ganjar, IG

Hakim, L

Timmerman, H

Verpoorte, R

机构：

[1] Gagjah Mada Univ, Fac Pharm, Yogyakarta 55281, Indonesia

[2] Hasanuddin Univ, Dept Pharmacol, Makassar, Indonesia

[3] Vrije Univ Amsterdam, Leiden Amsterdam Ctr Drug Res, Div Pharmacochem, Amsterdam, Netherlands

[4] Leiden Univ, Div Pharmacognosy, Leiden Amsterdam Ctr Drug Res, Leiden, Netherlands

来源：

PLANTA MEDICA | 2002年 / 68卷 / 11期

基金：

欧洲研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1055/s-2002-35650

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vitexicarpin was active in a model using sensitized guinea pig trachea stimulated by ovalbumin up to minimum dose of 1.3 x 10(-5) M. The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function.

引用

页码：1047 / 1049

页数：3

共 11 条

[1]

SPASMOLYTIC FLAVONOLS FROM ARTEMISIA-ABROTANUM [J].