Vascular disrupting agents

被引：225

作者：

Lippert, John W., III ^{[1
]}

机构：

[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12212 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 02期

关键词：

vascular targeting agents; vascular disrupting agents; anticancer; tubulin-binding agents;

D O I：

10.1016/j.bmc.2006.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A clear definition for vascular targeting agents (VTAs) and vascular disrupting agents (VDAs) has separated the two as distinct methods of cancer treatment. VDAs differ from VTAs (antiangiogenesis drugs) in their mechanism of action. VTAs attempt to keep new blood vessels from forming and do not act on blood vessels that already feed existing tumors. In contrast, VDAs cause the vascular structure inside a solid tumor to collapse, depriving the tumor of blood and oxygen it needs to survive. Therefore, VDAs are an attractive way to approach the cancer problem by combating developed tumors. The following review discusses six small molecule VDAs, namely DMXAA, ZD6126, TZT1027, CA4P, AVE8062, and Oxi4503, their synthesis, biological mechanism of action, and current clinical status. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：605 / 615

页数：11

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