SprE levels are growth phase regulated in a σS-dependent manner at the level of translation

被引：8

作者：

Gibson, KE ^{[1
]}

Silhavy, TJ ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 14期

关键词：

D O I：

10.1128/JB.182.14.4117-4120.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SprE regulates sigma(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is sigma(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and sigma(S) function within a regulatory feedback loop.

引用

页码：4117 / 4120

页数：4

共 18 条

[1] Regulation of RpoS proteolysis in Escherichia coli:: The response regulator RssB is a recognition factor that interacts with the turnover element in RpoS [J].

Becker, G ;

Klauck, E ;

Hengge-Aronis, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6439-6444

[2] Regulation of RssB-dependent proteolysis in Escherichia coli:: a role for acetyl phosphate in a response regulator-controlled process [J].

Bouché, S ;

Klauck, E ;

Fischer, D ;

Lucassen, M ;

Jung, K ;

Hengge-Aronis, R .

MOLECULAR MICROBIOLOGY, 1998, 27 (04) :787-795

[3] TRANSPOSITION AND FUSION OF LAC GENES TO SELECTED PROMOTERS IN ESCHERICHIA-COLI USING BACTERIOPHAGE-LAMBDA AND BACTERIOPHAGE-MU [J].

CASADABAN, MJ .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 104 (03) :541-555

[4] FLUOROGRAPHIC DETECTION OF RADIOACTIVITY IN POLYACRYLAMIDE GELS WITH THE WATER-SOLUBLE FLUOR, SODIUM-SALICYLATE [J].

CHAMBERLAIN, JP .

ANALYTICAL BIOCHEMISTRY, 1979, 98 (01) :132-135

[5]

HENGGEARONIS R, 1996, ESCHERICHIA COLI SAL, V1, P1497

[6]

HUISMAN G, 1994, REGULATION OF BACTERIAL DIFFERENTIATION, P21

[7]

Huisman G.W., 1996, ESCHERICHIA COLI SAL, P1672

[8] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[9] IDENTIFICATION OF A CENTRAL REGULATOR OF STATIONARY-PHASE GENE-EXPRESSION IN ESCHERICHIA-COLI [J].

LANGE, R ;

HENGGEARONIS, R .

MOLECULAR MICROBIOLOGY, 1991, 5 (01) :49-59

[10] The response regulator RssB controls stability of the sigma(S) subunit of RNA polymerase in Escherichia coli [J].

Muffler, A ;

Fischer, D ;

Altuvia, S ;

Storz, G ;

HenggeAronis, R .

EMBO JOURNAL, 1996, 15 (06) :1333-1339

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