Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

被引：40

作者：

Rolland, Julien ^{[1
]}

Cambeiro, Xacobe C. ^{[1
]}

Rodriguez-Escrich, Carles ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 5卷

关键词：

asymmetric synthesis; continuous flow; diarylmethanols; solid-supported catalyst; triarylboroxins; CATALYTIC ASYMMETRIC ARYLATION; PHENYL TRANSFER; BORONIC ACIDS; ORGANIC-SYNTHESIS; AMINO ALCOHOL; REAGENTS; DIARYLMETHANOLS; DIETHYLZINC; LIGANDS; HYDROGENATION;

D O I：

10.3762/bjoc.5.56

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

引用

页数：8

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