Added value and limitations of amyloid-PET imaging: review and analysis of selected cases of mild cognitive impairment and dementia

被引：9

作者：

Weidman, David A. ^{[1
]}

Zamrini, Edward ^{[2
]}

Sabbagh, Marwan N. ^{[2
]}

Jacobson, Sandra ^{[2
]}

Burke, Anna ^{[1
]}

Belden, Christine ^{[2
]}

Powell, Jessica ^{[2
]}

Bhalla, Nidhi ^{[2
]}

Roontiva, Auttawut ^{[1
]}

Kuang, Xiaoying ^{[1
]}

Luo, Ji ^{[1
]}

Chen, Kewei ^{[1
]}

Riggs, Garrett ^{[1
]}

Burke, William ^{[1
]}

机构：

[1] Banner Alzheimers Inst, Stead Family Memory Ctr, Phoenix, AZ 85006 USA

[2] Banner Sun Hlth Res Inst, Cleo Roberts Memory Ctr, Sun City, AZ USA

来源：

NEUROCASE | 2017年 / 23卷 / 01期

关键词：

Amyloid-PET; Alzheimer's disease; mild cognitive impairment; dementia; neuroimaging; POSITRON-EMISSION-TOMOGRAPHY; FLORBETAPIR F 18; APOLIPOPROTEIN-E EPSILON-4; ALZHEIMERS-DISEASE; DIAGNOSIS; IMPACT; FREQUENCIES; PREVALENCE; CONFIDENCE; PREDICTION;

D O I：

10.1080/13554794.2017.1290806

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyloid-positron emission tomography (PET) imaging of the brain detects elevated amyloid-beta (amyloid-) neuritic plaques in vivo, which can be helpful in appropriately selected cases of mild cognitive impairment (MCI) and dementia, when Alzheimer's disease remains a possible etiology, after a comprehensive clinical evaluation. We reviewed cases of cognitively impaired patients who underwent amyloid-PET imaging because of diagnostic uncertainty. Pre- and post-PET elements of diagnosis and management were first compared, to assess impact of scan results on clinical decision-making, and then an analysis of those decisions was undertaken in appropriate clinical situations, to delineate the added value and limitations of amyloid-PET imaging. The potential benefits and limitations of this diagnostic tool are important to understand in an era when the utility of such scans in clinical practice is evolving.

引用

页码：41 / 51

页数：11

共 41 条

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