Alzheimer's disease -: Closing in on γ-secretase

被引：32

作者：

De Strooper, B ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

NATURE | 2000年 / 405卷 / 6787期

关键词：

D O I：

10.1038/35015193

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

For decades, a short amyloid peptide called Aβ has been thought to underlie the neurodegeneration characteristic of Alzheimer's disease. This peptide is produced from a longer precursor protein by two protein-cleaving enzymes, known as β-secretase and γ-secretase. Presenilin, a suspect of old, is now revealed as the γ-secretase.

引用

页码：627 / 629

页数：2

共 15 条

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